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Cytokines

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Cytokines and Interleukins
Cytokines and Scleroderma
Cytokines and Sleep

Overview

Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis. Cytokines can cause inflammation associated with a variety of autoimmune diseases. (Also see Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Cytokine signature associated with disease severity in chronic fatigue syndrome patients (CFS). The physicians explored the role of cytokine in CFS and they explained that most of the cytokines were proinflammatory and probably contributed to many of the symptoms of CFS. PubMed, Proc Natl Acad Sci U S A, 2017 Aug 22;114(34):E7150-E7158. (Also see Chronic Fatigue Syndrome)

Cytokines and Interleukins

Overview
Anti-TNF-a Therapies
Interleukin-1{alpha}
Interleukin-6
Interleukin-8
Interleukin-10
Interleukin-12
Interleukin-13
Interleukin-16
Interleukin-17
Interleukin-18
Interleukin-20
Interleukin-21
Interleukin-22
Interleukin-23
Interleukin-25
Interleukin-27
Interleukin-33

Cytokines and Scleroderma

CCL3, IL-7, IL-13 and IFNγ transcripts are increased in skin's biopsy of systemic sclerosis (SSc). These molecules are involved in the pathogenesis of SSc, and how their interactions occur should be the subject of further studies. PubMed, Exp Dermatol, 06/04/2019. (Also see Skin Fibrosis)

Type I interferon dysregulation in Systemic Sclerosis. Here we describe the evidence of Type I IFN dysregulation in SSc, revealed predominately by genetics and gene expression profiling. PubMed, Cytokine, 01/23/2019.

A TNFSF13B functional variant is not involved in systemic sclerosis (SSc) and giant cell arteritis (GCA) susceptibility. Our data suggest that the TNFSF13B functional variant does not contribute to the genetic network underlying GCA and SSc. PubMed, PLoS One, 2018 Dec 26;13(12):e0209343.

Analysis of serum macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase in systemic sclerosis (SSc). Although not significantly linked to specific clinical parameters, serum MIF was significantly higher in SSc patients than in healthy controls and systemic lupus erythematosus patients. PubMed, Clin Transl Immunology, 2018 Dec 6;7(12):e1042.

Statins Inhibit Cytokines in a Dose–Dependent Response in Patients with Systemic Sclerosis (SSc). Statins, particularly simvastatin, appear to have an immunosuppressive effect in reducing all cytokine secretion levels from peripheral blood mononuclear cells of SSc in a dose–dependent manner. PubMed, Inflammation, 10/04/2018. (Also see Statins)

Different profile of cytokine production in patients with systemic sclerosis (Ssc) and association with clinical manifestations. SSc patients have a different profile of cytokine production and this was associated with clinical manifestations. PubMed, Immunol Lett, 2018 Mar 27;198:12-16.

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis (SSc). Hypomethylation of the IRF7 promoter might play a role in SSc pathogenesis, probably through promoting the IRF7 expression in peripheral blood mononuclear cells of patients with SSc. PubMed, Int J Rheum Dis, 09/26/2017.

Inflammasome lights up in systemic sclerosis. The innate immune system and small RNA molecules known as microRNA are key factors in the development of scleroderma. BioMed Central, Arthritis Res Ther, 2017; 19: 205.

Th–17 cytokines and interstitial lung involvement in systemic sclerosis (SSc). In diffuse SSc patients our results show a clear link between Th–17 cytokines measured both in exhaled breath condensate and in serum with interstitial lung involvement. PubMed, J Breath Re, 2016 Nov 21;10(4):046013. (Also see Pulmonary Fibrosis)

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology. (Also see Morphea and Ankylosing Spondylitis)

Cytokines and Sleep

Acute sleep fragmentation (SF) does not alter pro–inflammatory cytokine gene expression in brain or peripheral tissues of leptin–deficient mice. These findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. PubMed, PeerJ, 2018 Feb 19;6:e4423. (Also see Sleep Disorders and Illness)

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