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Cytokines

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Cytokines and Interleukins
Cytokines and Scleroderma
Cytokines and Sleep

Overview

Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis. Cytokines can cause inflammation associated with a variety of autoimmune diseases. (Also see Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Association Between Corrected QT (QTc) Interval and Inflammatory Cytokines in Rheumatoid Arthritis (RA). A lower inflammatory burden may protect against QTc prolongation in patients with RA. PubMed, J Rheumatol, 01/15/2015.

Cytokines and Interleukins

Overview
Anti-TNF-a Therapies
Interleukin-1{alpha}
Interleukin-6
Interleukin-8
Interleukin-10
Interleukin-12
Interleukin-13
Interleukin-17
Interleukin-20
Interleukin-22
Interleukin-23
Interleukin-25
Interleukin-27
Interleukin-33

Cytokines and Scleroderma

Th–17 cytokines and interstitial lung involvement in systemic sclerosis (SSc). In diffuse SSc patients our results show a clear link between Th–17 cytokines measured both in exhaled breath condensate and in serum with interstitial lung involvement. PubMed, J Breath Re, 2016 Nov 21;10(4):046013. (Also see Pulmonary Fibrosis)

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology. (Also see Morphea and Ankylosing Spondylitis)

Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis (SSc). The changes in concentrations of IL-17, IL-21 and IL-23 support the hypothesis that these cytokines may play a role in the pathogenesis of SSc. PubMed, Int J Rheum Dis, 2014 Jan 28.

Cytokines and Sleep

Sleep Impairment: A Trigger for Relapse in IBD? Certain cytokines are known to interfere with sleep, and sleep deprivation results in upregulation of cytokines. Medscape, 01/23/2014. (Also see Sleep Disorders and Illness)

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