Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Cytokines and Interleukins
Cytokines and Scleroderma
Cytokines and Sleep


Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis. Cytokines can cause inflammation associated with a variety of autoimmune diseases. (Also see Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Cytokine signature associated with disease severity in chronic fatigue syndrome patients (CFS). The physicians explored the role of cytokine in CFS and they explained that most of the cytokines were proinflammatory and probably contributed to many of the symptoms of CFS. PubMed, Proc Natl Acad Sci U S A, 2017 Aug 22;114(34):E7150-E7158. (Also see Chronic Fatigue Syndrome)

Association Between Corrected QT (QTc) Interval and Inflammatory Cytokines in Rheumatoid Arthritis (RA). A lower inflammatory burden may protect against QTc prolongation in patients with RA. PubMed, J Rheumatol, 01/15/2015.

Cytokines and Interleukins

Anti-TNF-a Therapies

Cytokines and Scleroderma

Different profile of cytokine production in patients with systemic sclerosis (Ssc) and association with clinical manifestations. SSc patients have a different profile of cytokine production and this was associated with clinical manifestations. PubMed, Immunol Lett, 2018 Mar 27;198:12-16.

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis (SSc). Hypomethylation of the IRF7 promoter might play a role in SSc pathogenesis, probably through promoting the IRF7 expression in peripheral blood mononuclear cells of patients with SSc. PubMed, Int J Rheum Dis, 09/26/2017.

Inflammasome lights up in systemic sclerosis. The innate immune system and small RNA molecules known as microRNA are key factors in the development of scleroderma. BioMed Central, Arthritis Res Ther, 2017; 19: 205.

Th–17 cytokines and interstitial lung involvement in systemic sclerosis (SSc). In diffuse SSc patients our results show a clear link between Th–17 cytokines measured both in exhaled breath condensate and in serum with interstitial lung involvement. PubMed, J Breath Re, 2016 Nov 21;10(4):046013. (Also see Pulmonary Fibrosis)

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology. (Also see Morphea and Ankylosing Spondylitis)

Cytokines and Sleep

Acute sleep fragmentation (SF) does not alter pro–inflammatory cytokine gene expression in brain or peripheral tissues of leptin–deficient mice. These findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. PubMed, PeerJ, 2018 Feb 19;6:e4423. (Also see Sleep Disorders and Illness)

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