Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Cytokines and Interleukins
Cytokines and Scleroderma
Cytokines and Sleep


Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis. Cytokines can cause inflammation associated with a variety of autoimmune diseases. (Also see Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Cytokine signature associated with disease severity in chronic fatigue syndrome patients (CFS). The physicians explored the role of cytokine in CFS and they explained that most of the cytokines were proinflammatory and probably contributed to many of the symptoms of CFS. PubMed, Proc Natl Acad Sci U S A, 2017 Aug 22;114(34):E7150-E7158. (Also see Chronic Fatigue Syndrome)

Association Between Corrected QT (QTc) Interval and Inflammatory Cytokines in Rheumatoid Arthritis (RA). A lower inflammatory burden may protect against QTc prolongation in patients with RA. PubMed, J Rheumatol, 01/15/2015.

Cytokines and Interleukins

Anti-TNF-a Therapies

Cytokines and Scleroderma

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis (SSc). Hypomethylation of the IRF7 promoter might play a role in SSc pathogenesis, probably through promoting the IRF7 expression in peripheral blood mononuclear cells of patients with SSc. PubMed, Int J Rheum Dis, 09/26/2017.

Inflammasome lights up in systemic sclerosis. The innate immune system and small RNA molecules known as microRNA are key factors in the development of scleroderma. BioMed Central, Arthritis Res Ther, 2017; 19: 205.

Th–17 cytokines and interstitial lung involvement in systemic sclerosis (SSc). In diffuse SSc patients our results show a clear link between Th–17 cytokines measured both in exhaled breath condensate and in serum with interstitial lung involvement. PubMed, J Breath Re, 2016 Nov 21;10(4):046013. (Also see Pulmonary Fibrosis)

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology. (Also see Morphea and Ankylosing Spondylitis)

Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis (SSc). The changes in concentrations of IL-17, IL-21 and IL-23 support the hypothesis that these cytokines may play a role in the pathogenesis of SSc. PubMed, Int J Rheum Dis, 2014 Jan 28.

Cytokines and Sleep

Sleep Impairment: A Trigger for Relapse in IBD? Certain cytokines are known to interfere with sleep, and sleep deprivation results in upregulation of cytokines. Medscape, 01/23/2014. (Also see Sleep Disorders and Illness)

Go to Dendritic Cells

Giving Assistant
United Way of Central New Mexico
United Way of Snohomish County
See ISN News for recent donors, including Pam Hop, Margaret Roof, Winifred Schillberg, Arnold Slotkin, and Juliet Youkhana. Plus donations in honor of Kim Thwaits, and in loving memory of Marta Marx, Jim Miller, and Arlene Marie Petulla.
Click Here to Donate or Shop
or click on the floating green DONATE button.


TOLL FREE HOTLINE, U.S. and Canada: 1-800-564-7099
Ask for our Free Info Packet by email or postal mail!

SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected] to request our Welcome email, or to report bad links or to update this page content. Privacy Policy.

The most important thing in the world to know about scleroderma is!

Donate Now
Copyright 1998-2018, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.