Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Cytokines and Interleukins
Cytokines and Scleroderma
Cytokines and Sleep


Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis. Cytokines can cause inflammation associated with a variety of autoimmune diseases. (Also see Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Cytokines, 25-OH vit D and disease activity in patients with juvenile-onset systemic lupus erythematosus (SLE). IFN-γ and IL-17 were significantly higher in JO-SLE patients, while 25-OH Vit D was significantly lower compared to controls. PubMed, Lupus, 2020 Nov 12;961203320973068. (Also see Pediatric Lupus)

Cytokine signature associated with disease severity in chronic fatigue syndrome patients (CFS). The physicians explored the role of cytokine in CFS and they explained that most of the cytokines were proinflammatory and probably contributed to many of the symptoms of CFS. PubMed, Proc Natl Acad Sci U S A. (Also see Chronic Fatigue Syndrome)

Cytokines and Interleukins

Anti-TNF-a Therapies

Cytokines and Scleroderma

Gastric Juice Expression of Th-17 and T-Reg Related Cytokines in Scleroderma Esophageal Involvement. This is the first report of cytokines measurement in gastric juice of patients with SSc. PubMed, Cells, 2020 Sep 16;9(9):E2106. (Also see Esophageal (Throat) Involvement)

CCL3, IL-7, IL-13 and IFNγ transcripts are increased in skin's biopsy of systemic sclerosis (SSc). These molecules are involved in the pathogenesis of SSc, and how their interactions occur should be the subject of further studies. PubMed, Exp Dermatol, 06/04/2019. (Also see Skin Fibrosis)

Type I interferon dysregulation in Systemic Sclerosis. Here we describe the evidence of Type I IFN dysregulation in SSc, revealed predominately by genetics and gene expression profiling. PubMed, Cytokine, 01/23/2019.

A TNFSF13B functional variant is not involved in systemic sclerosis (SSc) and giant cell arteritis (GCA) susceptibility. Our data suggest that the TNFSF13B functional variant does not contribute to the genetic network underlying GCA and SSc. PubMed, PLoS One, 2018 Dec 26;13(12):e0209343.

Analysis of serum macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase in systemic sclerosis (SSc). Although not significantly linked to specific clinical parameters, serum MIF was significantly higher in SSc patients than in healthy controls and systemic lupus erythematosus patients. PubMed, Clin Transl Immunology, 2018 Dec 6;7(12):e1042.

Statins Inhibit Cytokines in a Dose–Dependent Response in Patients with Systemic Sclerosis (SSc). Statins, particularly simvastatin, appear to have an immunosuppressive effect in reducing all cytokine secretion levels from peripheral blood mononuclear cells of SSc in a dose–dependent manner. PubMed, Inflammation, 10/04/2018. (Also see Statins)

Different profile of cytokine production in patients with systemic sclerosis (Ssc) and association with clinical manifestations. SSc patients have a different profile of cytokine production and this was associated with clinical manifestations. PubMed, Immunol Lett, 2018 Mar 27;198:12-16.

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology. (Also see Morphea and Ankylosing Spondylitis)

Cytokines and Sleep

Acute sleep fragmentation (SF) does not alter pro–inflammatory cytokine gene expression in brain or peripheral tissues of leptin–deficient mice. These findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. PubMed, PeerJ, 2018 Feb 19;6:e4423. (Also see Sleep Disorders and Illness)

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