Dendritic cells are involved in the regulation of the body's immune system response, and are thought to be a key to preventing or treating autoimmune diseases. (Also see: Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)
Plasmacytoid dendritic cells (pDC) promote systemic sclerosis (SSc) with a key role for TLR8. We conclude that the pDC is an essential cell type involved in the pathogenesis of SSc and its removal using depleting antibodies or attenuating pDC function could be a novel approach to treat SSc patients. PubMed, Sci Transl Med, 2018 Jan 10;10(423).
Dendritic cells (DC) maintain dermal adipose–derived stromal cells (ADSCs) in skin fibrosis. These findings provide insight into the effects of skin fibrosis on the dermal white adipose tissue ADSCs, identify a DC-ADSC survival axis in fibrotic skin, and suggest an approach for improving mesenchymal stromal cell therapy in scleroderma and other diseases. PubMed, 10/10/2016.
Contribution of Dendritic cells (DCs) to the autoimmune pathology of Systemic Lupus Erythematosus. In this review article the authors discuss the most relevant data relative to the contribution of DCs to the triggering of SLE. PubMed, Immunology, 07/17/2015.
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