Dendritic cells are involved in the regulation of the body's immune system response, and are thought to be a key to preventing or treating autoimmune diseases. (Also see: Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)
Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells (DCs) via retinoic acid-mediated regulatory T cell induction: A role in scleroderma (SSc). This study identified a critical role of dermal DCs as a regulator of Treg development through RALDH1 in bleomycin-treated mice and possibly in human SSc. PubMed, J Dermatol Sci, 01/15/2020.
Negative regulation of dendritic cell (DC) activation in psoriasis mediated via CD100-Plexin-B2. Our results uncovered a negative regulatory mechanism for DCs activation in psoriasis, which was mediated via CD100-Plexin-B2 in a cell type- and receptor- specific manner. PubMed, J Pathol, 01/14/2020. (Also see Psoriasis and Psoriatic Arthritis)
Anti-cancer Therapy May Help Fight Inflammation in Scleroderma (SSc) Patients, Data Suggest. These results suggest that tagraxofusp might be a potential therapeutic approach for SSc or other autoimmune diseases. Scleroderma News, 06/26/2019. (Also see Cancer)
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis (SSc) and contributes to enhanced fibrosis. We show at least two pathways potentially causing low runt-related transcription factor 3 level in SSc plasmacytoid dendritic cells. PubMed, Ann Rheum Dis, 05/24/2019.
Scientists Are Teaching the Body to Accept New Organs. Patients receiving new kidneys and livers must take damaging anti–rejection drugs for the rest of their lives, but now researchers hope to train the immune system instead of just tamping it down. New York Times, 01/22/2019. (Also see Immunosuppressants)
Plasmacytoid dendritic cells (pDC) promote systemic sclerosis (SSc) with a key role for TLR8. We conclude that the pDC is an essential cell type involved in the pathogenesis of SSc and its removal using depleting antibodies or attenuating pDC function could be a novel approach to treat SSc patients. PubMed, Sci Transl Med, 2018 Jan 10;10(423).
Contribution of Dendritic cells (DCs) to the autoimmune pathology of Systemic Lupus Erythematosus. In this review article the authors discuss the most relevant data relative to the contribution of DCs to the triggering of SLE. PubMed, Immunology.
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