Race and Ethnicity
Research progress in epigenetic studies on systemic sclerosis (SSc). In recent years, with the in-depth study of the epigenetics of SSc, the DNA methylation and miRNA has been the most widely studied. PubMed, Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2018 Dec 28;43(12):1369-1375.
Human Leukocyte Antigen (HLA) and Autoantibodies Define Scleroderma Subtypes and Risk in African and European Americans and Suggest a Role for Molecular Mimicry. These data suggest a possible link between HLA alleles, autoantibodies, and environmental triggers in the pathogenesis of systemic scleroderma. PubMed, Proc Natl Acad Sci U S A, 2020 Jan 7;117(1):552-562.
Racial differences in systemic sclerosis (SSc) disease presentation: a European Scleroderma Trials and Research group study. We evaluated differences in SSc presentations between white patients, Asian patients and black patients and analysed the effects of geographical locations. PubMed, Rheumatology (Oxford), 11/04/2019.
Ethnic Variations in Systemic Sclerosis (SSc) Disease Manifestations, Internal Organ Involvement, and Mortality. Ethnic variations in some SSc disease manifestations are observed, but this does not result in significant differences in short-term survival but may affect long-term survival. PubMed, J Rheumatol, 2019 Sep;46(9):1103-1108.
Deficient Adipogenesis of Scleroderma (SSc) Patient and Healthy African American (AA) Monocytes. Our observations strongly suggest that caveolin-1 and PPARγ work together to maintain a balance between the fibrogenic and adipogenic differentiation of monocytes, that this balance is altered in SSc and in healthy AA. PubMed, Front Pharmacol, 2017 Apr 3;8:174.
Early mortality in a multinational systemic sclerosis (SSc) inception cohort. Early mortality in SSc is substantial and prevalent cohorts underestimate mortality in SSc by failing to capture early deaths, particularly in men and those with diffuse disease. PubMed, Arthritis Rheumatol, 12/28/2016. (Also see Prognosis and Mortality)
Major Histocompatibility Complex (MHC) class II alleles, haplotypes, and epitopes which confer susceptibility or protection in the fibrosing autoimmune disease systemic sclerosis (SSc): analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls. These data indicate unique and multiple HLA class II effects in SSc, especially on autoantibody markers of different sub-phenotypes. Ann Rheum Dis.
Systemic sclerosis in Sarawak: a profile of patients treated in the Sarawak General Hospital. This study demonstrates the rarity of systemic sclerosis in a multi-ethnic groups, predominantly Chinese, Sarawak natives and Malays with considerable lag time to diagnosis. Diffuse cutaneous systemic scleroderma was more common with rare pulmonary hypertension and renal involvement.The Rheumatology International.
Genes and antibodies for scleroderma and its various symptoms can vary by geographic regions throughout the world. For example, Chinese systemic scleroderma patients typically have milder disease overall, but are more likely to have myositis (muscle inflammation) and certain autoantibodies than other ethnicities.
Lung and gastrointestinal complications are leading causes of death in SCORE, a multi-ethnic Singapore systemic sclerosis cohort. Pulmonary Arterial Hypertension, Interstitial Lung Disease and Gastrointestinal complications were leading causes of death in this cohort. We identified a high-risk group of patients who would benefit from closer monitoring and early intervention. PubMed, Scand J Rheumatol, 2016 Nov;45(6):499-506.
Single–specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis (SSc) subjects: clinical associations. This is the largest cohort to date focusing on the prevalence and disease characteristics of single–specificity anti-Ku antibodies in subjects with SSc. PubMed, Medicine (Baltimore). 2016 Aug;95(35):e4713. (Also see Antibodies)
Survival and causes of death in systemic sclerosis (SSc) patients: a single center registry report from Iran. In this first Middle Eastern series of SSc registry, pulmonary and cardiac involvements were the leading cause of SSc–related death. PubMed, Rheumatol Int, 2016 Jul;36(7):925-34.
Genetic susceptibility loci of idiopathic interstitial pneumonia (IIP) do not represent risk for systemic sclerosis (SSc): a case control study in Caucasian patients. Our results add new evidence that SSc and SSc-related interstitial lung disease are genetically distinct from IIP, although they share phenotypic similarities. PubMed, Arthritis Res Ther, 2016 Jan 20;18:20.
Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma (SSc). In Japanese patients, anti-PM/Scl antibodies are only very rarely found, and they are not always specific for dermatomyositis (DM) or SSc; they are also present in various autoimmune conditions PubMed, Arthritis Res Ther. (Also see Antibodies)
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