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Causes of Scleroderma: Natural Killer Cells

Natural killer cells are cells in the immune system that destroy cancer cells and virus-infected cells.

Natural Killer (NK) Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases? Because of its role in modulating the immune-mediated pathology, NK subpopulation could represent a potential marker for disease activity and target for therapeutic intervention. PubMed, Front Immunol, 2021 Feb 19;12:616853.

Changes of frequency and expression level of CD161 in CD8 + T cells and natural killer (NKC) T cells in peripheral blood of patients with systemic lupus erythematosus (SLE). The frequencies and levels of CD161 expression on CD8+ T cells and NKT cells were reduced in SLE patients, suggesting that an abnormality of these cells was related to the pathogenesis of SLE. PubMed, Microbiol Immunol, 2020 Jul;64(7):532-539.(Also see B Cells and T Cells)

Adaptive Features of Natural Killer (NK) Cells in Multiple Sclerosis (MS). Our results provide novel insights into the putative influence of Human cytomegalovirus and adaptive NK cells in MS. PubMed, Front Immunol, 2019 Oct 15;10:2403. (Also see Multiple Sclerosis)

The Good and the Bad of Natural Killer Cells in Virus Control: Perspective for Anti-hepatitis B virus (HBV) Therapy. This review outlines the main NK cell features with a particular focus on chronic hepatitis B infection. PubMed, Int J Mol Sci, 2019 Oct 13;20(20).

Cytometric Characterization of Main Immunocompetent Cells in Patients with Systemic Sclerosis (SSc): Relationship with Disease Activity and Type of Immunosuppressive Treatment. In SSc patients, increment of T double positive and reduction of T double negative as well as natural killer and natural killer T cells were observed. PubMed, J Clin Med, 2019 May 8;8(5).

Human Cytomegalovirus Antigen Presentation (HCMV) by HLA-DR+ NKG2C+ Adaptive Natural Killer (NK) Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes. Our data discloses the capacity of NKG2C+ adaptive NK cells to process and present HCMV antigens to memory CD4+ cytotoxic T cells, directly regulating their response to the viral infection. PubMed, Front Immunol, 2019 Apr 3;10:687. (Also see Antibodies)

Cytotoxic Function and Cytokine Production of Natural Killer (NK) Cells and Natural Killer T-Like (NKT-like) Cells in Systemic Lupus Erythematosis Regulation (SLE) with Interleukin-15 (IL-15). Higher granzyme B expression of NK and NKT-like cells in active SLE patients, further enhanced by circulating IL-15, may contribute to the maintenance of inflammation in SLE. PubMed, Mediators Inflamm, 2019 Mar 31;2019:4236562. (Also see Causes of Lupus)

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