Causes of Scleroderma: Natural Killer Cells

Natural killer cells are cells in the immune system that destroy cancer cells and virus-infected cells.

Adaptive Features of Natural Killer (NK) Cells in Multiple Sclerosis (MS). Our results provide novel insights into the putative influence of Human cytomegalovirus and adaptive NK cells in MS. PubMed, Front Immunol, 2019 Oct 15;10:2403. (Also see Multiple Sclerosis)

The Good and the Bad of Natural Killer Cells in Virus Control: Perspective for Anti-hepatitis B virus (HBV) Therapy. This review outlines the main NK cell features with a particular focus on chronic hepatitis B infection. PubMed, Int J Mol Sci, 2019 Oct 13;20(20).

Cytometric Characterization of Main Immunocompetent Cells in Patients with Systemic Sclerosis (SSc): Relationship with Disease Activity and Type of Immunosuppressive Treatment. In SSc patients, increment of T double positive and reduction of T double negative as well as natural killer and natural killer T cells were observed. PubMed, J Clin Med, 2019 May 8;8(5).

Human Cytomegalovirus Antigen Presentation (HCMV) by HLA-DR+ NKG2C+ Adaptive Natural Killer (NK) Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes. Our data discloses the capacity of NKG2C+ adaptive NK cells to process and present HCMV antigens to memory CD4+ cytotoxic T cells, directly regulating their response to the viral infection. PubMed, Front Immunol, 2019 Apr 3;10:687. (Also see Antibodies)

Activating and inhibitory receptors on natural killer cells in patients with systemic lupus erythematosis (SLE)–regulation with interleukin-15. Natural killer (NK) cells may play an important role in the pathogenesis of SLE. PubMed, PLoS One, 2017 Oct 12;12(10):e0186223. (Also see Causes of Lupus)

Analysis of the CD161–expressing cell quantities and CD161 expression levels in peripheral blood natural killer (NK) and T cells of systemic lupus erythematosus patients. Our results indicated that CD161–expressing cell frequency and the CD161 expression levels were reduced in some NK and T cell subpopulations of SLE patients, suggesting possible important role of CD161 and CD161–expressing immune cells in the SLE pathogenesis. PubMed, Clin Exp Med, 2017 Feb;17(1):101-109. (Also see B Cells and T Cells)

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