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Causes of Scleroderma: Oxidative Stress, Lipid Peroxidation

Oxidative stress is an imbalance between pro-oxidants and antioxidants that can result in cellular degeneration. Oxidative stress is characterized by the release of free radicals, highly reactive molecules that can steal electrons from lipids resulting in cellular damage, a process referred to as lipid peroxidation.

Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress. The cytochrome c release into the extracellular space and tryptase may have a role in skin and joint inflammation. PubMed, Front Immunol, 2018 Oct 30;9:2363. (Also see Psoriasis and Psoriatic Arthritis)

Frequency of audiological complaints in patients with fibromyalgia syndrome (FMS) and its relationship with oxidative stress. Patients with FMS have high levels of oxidative stress markers, highly frequent audiological symptoms with high hearing frequencies in audiometry, independent of disease severity. PubMed, Niger J Clin Pract, 2018 Oct;21(10):1271-1277. (Also see Fibromyalgia)

A Potential Link Between Oxidative Stress and Endothelial–to–Mesenchymal Transition (EndMT) in Systemic Sclerosis (SSc). We identified studies investigating associations reactive oxygen species and EndMT highlighting a potential link between oxidative stress and EndMT in SSc. PubMed, Front Immunol, 2018 Sep 19;9:1985.

Oxidative stress in autoimmune rheumatic diseases. The detection of autoantibodies against specific antigens, might improve both early diagnosis and monitoring of disease activity. PubMed, Free Radic Biol Med, 05/30/2018.

The role of oxidative stress in the relation between fibromyalgia (FMS) and obstructive sleep apnea syndrome (OSAS). OSAS and FMS were highly prevalent, which indicated that oxidative stress might play a role in the pathophysiology of both diseases, especially if they co–exist in the same patient. PubMed, Eur Rev Med Pharmacol Sci, 2017 Jan;21(1):20-29. (Also see Sleep Apnea and Fibromyalgia)

Bone marrow–derived mesenchymal stem cells (BMSCs) expressing thioredoxin 1 attenuate bleomycin–induced skin fibrosis and oxidative stress in scleroderma (SSc). These results demonstrate that the transplantation of Trx–1–overexpressing BMSCs restored normal skin tissue in a mouse model of bleomycin–induced SSc, highlighting the therapeutic potential of engineered BMSCs for treating SSc. PubMed, J Invest Dermatol, 01/26/2017. (Also see Causes of Scleroderma: Drugs and Medications)

Oxidative stress parameters in localized scleroderma patients. Oxidative stress seems to be effective in the pathogenesis of localized scleroderma and arylesterase levels have increased in morphea patients. PubMed, Arch Dermatol Res, 09/03/2016.

Exercise in systemic sclerosis (SSc) intensifies systemic inflammation and oxidative stress. Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. PubMed, Scand J Rheumatol.

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