Deficiencies of Vit D
|Scleroderma and Vit D
Vitamin D's major biological function is to maintain normal blood levels of calcium and phosphorus. Recent studies have demonstrated that individuals with low blood levels of vitamin D are at a higher risk of developing autoimmune diseases.
Effects of Vitamin D on disease activity and serum interleukin-6 in rheumatoid arthritis (RA). This study suggests that vitamin D is not associated with disease activity or serum IL-6 levels but it may have a role in functional disability in RA patients. PubMed, Int J Rheum Dis, 02/06/2019. (Also see Diagnosis of Rheumatoid Arthritis)
Vitamin D in Vascular Calcification (VC): A Double-Edged Sword? This review addresses the current understanding of VC pathophysiology, with a focus on the pathogenic role of vitamin D that has provided new insights into the mechanisms of VC. PubMed, Nutrients. 2018 May 22;10(5). (Also see Vascular Involvement)
Associations between vitamin D receptor polymorphisms and susceptibility to Behçet's disease: A meta–analysis. This meta–analysis demonstrated the association between FokI and ApaI polymorphisms in VDR gene with the risk of BD. PubMed, Immunol Invest, 2018 Feb 1:1-14. (Also see Behçet's Disease)
Vitamin D could prevent rheumatoid arthritis – but much higher doses may be required in already–affected sufferers. New research reveals the so-called 'sunshine supplement' strengthens the immune system, which helps to prevent the body from attacking healthy cells and causing autoimmune conditions, such as arthritis. Mail Online, 11/21/2017.
Vitamin D Treatment in Patients with Hashimoto's Thyroiditis may Decrease the Development of Hypothyroidism. Vitamin D deficiency is frequent in Hashimoto's thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. PubMed, Int J Vitam Nutr Res, 2017 Jul 12:1-9. (Also see Hashimoto's Thyroiditis)
Vitamin D deficiency is associated with digital ulcer (DU) but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study. Vitamin D deficiency was associated with DUs, but not with atherosclerosis or arterial stiffness, potentially indicating that vitamin D may have different effects on the microvascular and macrovascular involvement in SSc pathophysiology. PubMed, Clin Rheumatol, 2017 Jun;36(6):1325-1333. (Also see Digital Ulcers and Cardiac (Heart) Involvement)
Vitamin D level in rheumatoid arthritis (RA) and its correlation with the disease activity: a meta–analysis. Our meta–analysis suggests that the vitamin D level is associated with susceptibility to RA and RA activity. PubMed, Clin Exp Rheumatol. 2016 Sep-Oct;34(5):827-833. (Also see Rheumatoid Arthritis Treatments)
Vitamin D, disease activity and comorbidities in early spondyloarthritis. In early axial spondyloarthritis vitamin D deficiency was associated with higher disease activity and severity and presence of metabolic syndrome. PubMed, Clin Exp Rheumatol, 04/05/2016. (Also see Ankylosing Spondylitis)
Do I Get Enough Vitamin D in the Winter? Most people can make enough vitamin D from sun exposure during the summer, but for many, synthesis can be inadequate in the winter. New York Times, 02/16/2018.
Association between serum vitamin D levels and neuropathic pain (NP) in rheumatoid arthritis (RA) patients: A cross–sectional study. Although further research is needed to clarify the association between serum vitamin D levels and NP, our study raises awareness of the need to screen for vitamin D deficiency in RA patients with NP. PubMed, Int J Rheum Dis, 08/31/2017. (Also see Symptoms and Complications of Rheumatoid Arthritis)
Vitamin D levels in systemic sclerosis (SSc) patients: a meta-analysis. We hypothesize that SSc patients, especially diffused type, have lower vitamin D levels, and that the decrease of vitamin D levels might not be an accelerating factor of SSc severity. PubMed, Drug Des Devel Ther, 2017 Oct 27;11:3119-3125.
Endothelin-1, α-Klotho, 25(OH) Vit D levels and severity of disease in scleroderma (SSc) patients. Although our study revealed higher serum ET-1 and lower serum α-Klotho levels in SSc patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement. PubMed, Rheumatol Int, 2017 Oct;37(10):1651-1657.
How Sunlight Affects Your Mental Health. A new study suggests just how much sunlight really matters to our emotional and mental health, more than any other weather phenomenon. Time Healthland, 11/07/2016.
New research shows vitamin D could lower risk of colorectal cancer. The American Cancer Society found having higher vitamin D levels than are currently recommended reduced the risk of colorectal cancer by 22 percent. NBC News, 06/14/2018. (Also see Cancer)
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