Specialized blood tests such as antinuclear antibody (ANA) tests are sometimes useful in the diagnosis or categorization of both localized and systemic scleroderma, as well as overlapping or other autoimmune diseases. (Also see:What is Scleroderma?, Types of Scleroderma and Systemic Symptoms)
Functional autoantibodies in systemic sclerosis (SSc) pathogenesis. Functional autoantibodies could represent a significant piece in the puzzle of SSc pathogenesis and may open new gateways and opportunities for therapeutic intervention. PubMed, Curr Rheumatol Rep, 2015 May;17(5):505.
ESR: Erythrocyte Sedimentation Rate. There are different methods of obtaining the SED rate--such as Westergren, Cutler, Wintrobe, and Smith--and what is considered normal will depend on the method used. This test can be used to monitor inflammatory or cancerous diseases. It is a screening test, which means it cannot be used to diagnose a specific disorder. Medline Plus.
ANCA and Anti-PR3
AT1R and ETAR
DNA, Topoisomerase I
|ESR (Sed Rate)
PmScl and dsDNA
TNF and IL-13
IgG or IgM anti-Cu/Zn SOD antibody was detected in the serum of 89% of localized scleroderma patients, especially 100% of patients with generalized morphea, the severest form of localized scleroderma, but was positive only in the serum of less than 15% of patients with other autoimmune disorders, including systemic sclerosis, systemic lupus erythematosus, dermatomyositis, and autoimmune bullous disorders. Journal of Investigative Dermatology. (Also see Generalized Morphea)
Antinucleosome antibody is a major autoantibody in localized scleroderma. Although antinucleosome antibody was not specific to localized scleroderma, its high prevalence in localized scleroderma indicates that antinucleosome antibody is a major autoantibody in this disease. PubMed, Br J Dermatol. (Also see Localized Scleroderma)
Antibodies in Lupus. There are over 100 antibodies associated with lupus. ISN.
Elucidation of the potential disease-promoting influence of IgM apoptotic cell–reactive antibodies in lupus. Apoptotic cell-reactive IgM antibodies may be potentially capable of influencing the course of systemic autoimmune disease by affecting both innate and adaptive immunity. Lupus, 01/06/2016.
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