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Research about Scleroderma Cardiac (Heart) Involvement

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Antibodies
Autoimmunity and Heart Disease
Causes of Heart Disease

Antibodies

Predicting cardiopulmonary involvement in patients with systemic sclerosis: complementary value of nailfold videocapillaroscopy (NVC) patterns and disease–specific autoantibodies. All SSc–specific auto–antibodies were found, with ACA and anti-Scl-70 being the most prevalent and the association between NVC–pattern and heart/lung involvement was independent of specific anti-ENA antibodies, which might indicate microangiopathy is an important cause of organ involvement. PubMed, Rheumatology (Oxford), 12/10/2016. (Also see Antibodies and Nailfold Videocapillaroscopy)

Autoimmunity and Heart Disease

Free light chains (FLC) of immunoglobulins in patients with systemic sclerosis (SSc): correlations with lung involvement and inflammatory milieu. FLC levels are elevated in SSc and high levels are associated with lung involvement and with a higher degree of inflammation, supporting a possible role of B cell activation in the pathophysiology of the disease. PubMed, J Clin Pathol, 01/31/2018. (Also see Pulmonary Fibrosis Correlations)

Causes of Heart Disease in Systemic Autoimmune Diseases

No changes in N-terminal pro–brain natriuretic peptide (NT-proBNP) in a longitudinal cohort of patients with systemic sclerosis–associated pulmonary arterial hypertension on therapy with bosentan. NT-proBNP may lack 'sensitivity to change', but further studies are warranted to assess the role of NT-proBNP as a biomarker of the therapeutic response in larger cohorts of SSc patients. PubMed, Int J Rheum Dis, 2017 Jan;20(1):90-96.

Left Ventricular Mass (LVM) and Intrarenal Arterial Stiffness as Early Diagnostic Markers in Cardiorenal Syndrome(CRS) Type 5 due to Systemic Sclerosis. LVM and intrarenal arterial stiffness can be considered as early markers of CRS onset and the clinical use of these markers permits a prompt identification of organ damage. PubMed, Cardiorenal Med, 2016 Feb;6(2):135-42.

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