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Research about Scleroderma Cardiac (Heart) Involvement

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Autoimmunity and Heart Disease
Causes of Heart Disease


Progression of nailfold capillaroscopic patterns and correlation with organ involvement in systemic sclerosis: a 12 year study. This longitudinal study confirms over a 12-year follow-up the evolution of specific NVC patterns associated with the progressive severity of organ involvement in SSc patients in a standard clinical care setting. PubMed, Rheumatology (Oxford), 2020 May 1;59(5):1051-1058. (Also see Antibodies and Nailfold Videocapillaroscopy)

Clinical Manifestation and Incidence of Cardiopulmonary Complications in Early Systemic Sclerosis (SSc) Patients with Different Antibody Profiles. It was found that the presence of SSc-specific autoantibodies was associated with a distinctive clinical presentation and cumulative internal organ involvement, even in the early phase of the disease. PubMed, J Clin Med Res, 2019 Jul;11(7):524-531. (Also see Antibodies)

Autoimmunity and Heart Disease

Free light chains (FLC) of immunoglobulins in patients with systemic sclerosis (SSc): correlations with lung involvement and inflammatory milieu. FLC levels are elevated in SSc and high levels are associated with lung involvement and with a higher degree of inflammation, supporting a possible role of B cell activation in the pathophysiology of the disease. PubMed, J Clin Pathol, 01/31/2018. (Also see Pulmonary Fibrosis Correlations)

Causes of Heart Disease in Systemic Autoimmune Diseases

T Cells in Autoimmunity-Associated Cardiovascular Diseases (CVD). In the future, T cells are likely to represent major targets for the prevention and treatment of CVD in patients with autoimmune diseases. PubMed, Front Immunol, 2020 Oct 7;11:588776. (Also see B Cells and T Cells)

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