Correlation with other Complications
When the stomach is affected, it is often called gastroparesis.
When it affects the bowels, it may be called intestinal pseudo-obstruction. (Also see Esophagus, Gastroparesis, Scleroderma Gastrointestinal Involvement, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis
Dysmotility syndrome is a vague, descriptive term used to describe diseases of the muscles of the gastrointestinal tract (esophagus, stomach, small and large intestines) in which the muscles do not work normally (hence the term dysmotility). Other terms that are sometimes used for dysmotility problems are gastroparesis when the stomach is involved, and chronic intestinal pseudo-obstruction when the intestines and stomach are involved. MedicineNet.
What are Dysmotilities? Symptoms, diagnosis, treatments, and support. Gastroparesis and Dysmotilities Association.
The Gastrointestinal dysmotility and infections in Systemic Sclerosis – A real world scenario. Motility abnormalities in the esophagus make them prone for super added infections and should be investigated for early detection and treatment. PubMed, Curr Rheumatol Rev, 04/25/2017.
Anorectal Motility and Sensation Abnormalities and Its Correlation with Anorectal Symptoms in Patients with Systemic Sclerosis (SSc): A Preliminary Study. Eight SSc patients and matched controls were queried about their GI dysmotility symptoms and quality of life (QoL) and underwent anorectal motility and sensory tests. ISRN Gastroenterology.
The role of high-resolution manometry in the assessment of upper gastrointestinal involvement in systemic sclerosis: a systematic review. Esophageal body dysmotility on HRM positively correlates with the presence of interstitial lung disease. PubMed, Clin Rheumatol, 11/11/2019. (Also see Correlation between Pulmonary Fibrosis and other Diseases)
Anti-RNPC3 (U11/U12) antibodies in systemic sclerosis are associated with moderate to severe gastrointestinal dysmotility. After adjusting for relevant covariates and potential confounders, moderate to severe GI disease was associated with anti-RNPC3 antibodies. PubMed, Arthritis Care Res (Hoboken), 09/22/2018. (Also see Antibodies)
Intestinal Motility Disorders Differential Diagnoses. Failure to make the correct diagnosis of an intestinal motility disorder is a medicolegal pitfall, especially in patients with irritable bowel syndrome (IBS), because several cancers of the digestive tract mimic this condition, even in late stages. Medscape.
Esophageal symptoms and their lack of association with high–resolution manometry (HRM) in systemic sclerosis patients. There was no clear association between symptomatology and HRM findings and HRM does not seem to accurately predict upper gastrointestinal symptomatology. PubMed, Reumatol Clin, 12/16/2017.
Spectrum of esophageal dysmotility in systemic sclerosis on high–resolution esophageal manometry as defined by Chicago classification. The severity of gastroesophageal reflux disease related endoscopic findings correlated with the degree of esophageal dysmotility on high–resolution esophageal manometry. PubMed, Dis Esophagus, 2017 Dec 1;30(12):1-6.
Frequency of motor alterations detected through manometry in patients with esophageal symptoms and scleroderma. Scleroderma is associated with lower esophageal sphincter alterations and symptomatic ineffective esophageal motility. PubMed, Rev Gastroenterol Mex, 2017 Apr - Jun;82(2):193-195.
Transcutaneous Electrical Nerve Stimulation (TENS) Improves Upper GI Symptoms and Balances the Sympathovagal Activity in Scleroderma Patients. TENS at GI acupoints offers a potential option in the treatment of upper GI symptoms, but further study is necessary. PubMed, Dig Dis Sci.
Systematic review: pathophysiology and management of gastrointestinal dysmotility in systemic sclerosis. Lifestyle and medical therapy approaches are preferred as they often improve and/or ameliorate symptoms. Surgery is only recommended with serious, rare complications. Alternative therapies such as acupuncture-based therapies are well tolerated, with clinical improvement and may be of potential therapeutic benefit for systemic sclerosis gastrointestinal dysmotility. PubMed, Aliment Pharmacol Ther.
FDA Alert: Detention without Physical Examination of Domperidone, brands names Motilium, Euciton, Cilroton, Praxis, Seronex, Emiken. Domperidone is not approved for any use in the U.S. There have been several published reports and case studies of cardiac arrhythmias, cardiac arrest and sudden death in patients receiving an intravenous form of domperidone. U.S. Food and Drug Administration (FDA). 2004.
Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review. In this review, we discuss disorders of the thyroid-gut axis and identify the evidence base behind the management of such disorders. PubMed, Eur J Intern Med. (Also see Thyroid Disease and Liver Involvement)
Amanda: Diffuse Scleroderma Systemic Sclerosis I am thirty-nine years old and was diagnosed with diffuse scleroderma systemic sclerosis in August 2007…
The 5-HT1A receptor agonist buspirone improves esophageal motor function and symptoms in systemic sclerosis: a 4-week, open-label trial. More conclusive evaluation is needed; however, buspirone could potentially be given under observation for objective improvement in all patients with SSc who report reflux symptoms despite undergoing standard treatment. BioMed Central, Arthritis Research & Therapy, 09/01/2016. (Also see Scleroderma Clinical Trials)
Possible implications of TGF-alpha in eosophageal dysmotility in systemic sclerosis (SSc). These results point to a possible relation between TGF-a and oesophageal dysmotility in SSc, which is intriguing and requires further investigation. PubMed, Clin Exp Rheumatol.
In Loving Memory of Lorraine Wempner, a donation to tackle scleroderma has been made by Paul Wempner. Posted 11/13/2019. (Also see: ISN News)
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