Overview of Scleroderma and Inflammatory Bowel Disease

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Correlation with Other Diseases
Collagenous Colitis
Crohn's Disease
Ulcerative Colitis
Support for IBD


These symptoms may occur by themselves or along with other diseases such as systemic scleroderma but not in localized scleroderma, such as linear and morphea.

Abstract collageInflammatory Bowel Disease (IBD) should not be confused with Irritable Bowel Syndrome (IBS) which is less severe. In particular, collagenous colitis should be suspected in systemic scleroderma patients who develop watery diarrhea.

Systemic scleroderma can also occur in overlap with Crohn's disease and ulcerative colitis.

(Also see: Scleroderma Gastrointestinal Involvement, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Inflammatory Bowel Disease: Effects on Bone and Mechanisms. Intestinal microbial metabolites such as H2S may also affect bone cell function and uncovering these mechanisms will enable the design of microbial cocktails to help restore bone mass in patients with IBD. PubMed, Adv Exp Med Biol,2017;1033:133-150.

Systematic Review of Complementary and Alternative Medicine Treatments in Inflammatory Bowel Diseases. Complementary and alternative therapies might be effective for the treatment of inflammatory bowel diseases; however, given the low number of trials and the heterogeneous methodological quality of trials, further in-depth research is necessary. PubMed, J Crohns Colitis, 2015 Jan;9(1):86-106. (Also see Alternative Therapies)

IBD vs. IBS. Unlike IBD, IBS does not cause inflammation, ulcers or other damage to the bowel. Instead, IBS is a much less serious problem called a functional disorder. WebMD.

IBD in Correlation with Other Diseases

Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis (PsA): a population–based cohort study. In a primary care–based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls. PubMed, Ann Rheum Dis, 11/01/2017. (Also see Psoriasis and Psoriatic Arthritis)

Inflammatory Bowel Diseases (IBD) in Children and Young Adults with Celiac Disease (CD). A Multigroup Matched Comparison. This article found a highly increased risk of IBD in individuals with CD when comparing with the general population. PubMed, Inflamm Bowel Dis, 2017 Nov;23(11):1996-2000. (Also see Celiac Disease)

Patients with inflammatory bowel disease (IBD) have increased risk of autoimmune and inflammatory diseases. Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some immune mediated diseases and IBD's may have overlapping pathogenic pathways. PubMed, World J Gastroenterol, 2017 Sep 7;23(33):6137-6146.

Collagenous Colitis

Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. Collagenous colitis should be suspected as a rare gastrointestinal complication of systemic sclerosis and clinicians should be aware of the possibility in SSc patients developing watery diarrhea. PubMed, J Clin Rheumatol, 2014 Aug;20(5):278-82.

Crohn's Disease

Crohn's Disease is an inflammatory bowel disease, the general name for diseases that cause swelling in the intestines. Because the symptoms of Crohn's disease are similar to other intestinal disorders, such as irritable bowel syndrome and ulcerative colitis, it can be difficult to diagnose. National Digestive Diseases Information Clearinghouse.

The current therapeutic options for Crohn's disease (CD): from medical therapy to intestinal transplantation. CD treatment is mainly medical, leaving endoscopy and surgery for a complex course. PubMed, Expert Rev Gastroenterol Hepatol, 08/14/2017.

Systemic Sclerosis Patients Have Reduced Incidence of Crohn’s Disease, According to Study. The findings led the team to conclude that systemic sclerosis is associated with a reduced incidence of Crohn’s disease, regardless of the patient’s age and sex. Scleroderma News, 09/24/2015.

Objectively measured muscle fatigue in Crohns disease. Subjects with Crohns disease had more muscle fatigue than matched healthy controls and this correlated well with self–reported fatigue. PubMed, Journal of Crohn's and Colitis, 2014 Feb;8(2):137-46. (Also see Crohns Disease)

Ulcerative Colitis

Ulcerative colitis is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. Ulcerative colitis is an inflammatory bowel disease, the general name for diseases that cause inflammation in the small intestine and colon. It can be difficult to diagnose because its symptoms are similar to other intestinal disorders and to another type of IBD called Crohn's disease. National Digestive Diseases Information Clearinghouse.

The application of molecular topology for ulcerative colitis drug discovery. These and other similar studies applying molecular topology suggest that some therapeutic categories may present a 'topological pattern' that goes beyond a specific mechanism of action. PubMed, Expert Opin Drug Discov, 2017 Nov 1:1-13.

Support for IBD

Crohn's & Colitis Foundation of America. Our Mission is to cure Crohn's disease and ulcerative colitis, and to improve the quality of life of children and adults affected by these diseases. Crohn's & Colitis Foundation of America.

IBD Support Foundation. The IBD Support Foundation focuses on providing comprehensive, patient-centered psychosocial care. IBD Support Foundation.

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