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Pulmonary Fibrosis Treatments: Lung Transplants

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview Media Stories

Overview

Landscape by Janet Paulmenn, ISN ArtistLung Transplants, in most cases, are a treatment of last resort. This is because lung transplants are a very invasive procedure and they require a lung donor.

This procedure is also extremely expensive compared to other treatments. However, lung transplants have been proven to be effective for patient with scleroderma related pulmonary fibrosis.

Lung Transplant Discussions on Sclero Forums conversations including transplant testing and evaluation. ISN Sclero Forums.

Lung Transplantation in Patients With Systemic Sclerosis. Multiple recent reports provide convincing findings that scleroderma patients undergoing lung transplantation have similar outcomes as those with other non–rheumatologic pulmonary conditions, even when significant esophageal dysmotility is present. PubMed, Curr Rheumatol Rep, 2017 May;19(5):23.

Lung Transplant Outcomes in Systemic Sclerosis (SSc) with Significant Esophageal Dysfunction: A Comprehensive Single Center Experience. Relative to other lung transplant indications, our SSc group experienced comparable survival, despite the high prevalence of severe esophageal dysfunction. PubMed, Ann Am Thorac Soc, 04/14/2016.

Survival of adults with systemic sclerosis following lung transplantation: A nationwide cohort study. A diagnosis of SSc may confer an increased risk of death 1 year following lung transplantation compared to a diagnosis of ILD, but this risk is similar to that of PAH, a widely accepted indication for lung transplantation. PubMed, Arthritis Rheumatol, 01/07/2015. (Also see What is Scleroderma?)

Usefulness of pH monitoring in predicting the survival status of patients with scleroderma awaiting lung transplantation. Esophageal pH monitoring could identify those for whom laparoscopic antireflux surgery should be performed quicker to prevent GERD and its detrimental effects in patients awaiting lung transplantation. Journal of Surgical Research. (Also see Reflux, Heartburn, GERD)

United Network for Organ Sharing. Resources for all aspects of organ transplantation. UNOS.

Lung Transplant. Lung transplant can benefit patients with advanced lung disease for which medical therapies are not effective. These lung diseases include pulmonary fibrosis, connective tissue disease, emphysema, pulmonary hypertension, sarcoidosis, lymphangioleiomyomatosis (LAM), pneumoconiosis, bronchoalveolar carcinoma (BAC), bronchiectasis, and cystic fibrosis (CF). Duke Medicine.

NHS Blood and Transplant. Resources for all types of transplants in the United Kingdom (UK). NHS.

Media Stories

Breakthrough shows a discarded diabetes drug could prevent life–threatening complications after heart transplant surgery. A discarded diabetes drug could be the key to beating organ transplant rejection, a landmark study has found. Mail Online, 11/21/2017.

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