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Uptravi® (Selexipag) for Pulmonary Hypertension

Author: Jo Frowde. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Uptravi is marketed by San Francisco-based Actelion Pharmaceuticals US, Inc.

Uptravi by Actelion is an oral medication for PAHUptravi® (selexipag) is an oral IP prostacyclin receptor agonist marketed by Actelion Pharmaceuticals US, Inc., which was approved by the US FDA for the treatment of pulmonary arterial hypertension in December 2015. Common side effects include headache, diarrhea, jaw pain, nausea, muscle pain (myalgia), vomiting, pain in an extremity, and flushing. ISN.

Selexipag. About this treatment for pulmonary hypertension, including the GRIPHON clinical trial results, safety and tolerability, and dosing information. Actelion.

Selexipag for the treatment of connective tissue disease–associated pulmonary arterial hypertension (PAH). Selexipag delayed progression of PAH and was well–tolerated among PAH–Connective Tissue Disease patients, including those with PAH–Scleroderma and PAH–Systemic Lupus Erythematosus. PubMed, Eur Respir J, 2017 Aug 17;50(2).

FDA Clears Uptravi® (Selexipag) for Pulmonary Arterial Hypertension. Uptravi® (selexipag) was shown to be effective in reducing hospitalization for pulmonary arterial hypertension (PAH) and reducing the risks of disease progression compared to placebo. FDA, 12/22/2015. (Also see: Pulmonary Hypertension Treatments)

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