SCLERO.ORG
Search

Symptoms and Complications of Sjogren's Syndrome

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Cardiovascular
Central Nervous System
Dry Eyes
Dry Mouth
Dry Vagina
Fatigue
Fibromyalgia
Liver
Pulmonary
Renal
Skin
Newborn Heart Problems
Sjogren's and Pregnancy

Overview

Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions.

Symptoms of Sjogren's Syndrome. Sjögren's is a systemic disease, and its symptoms are felt throughout the entire body. Sjogren's Syndrome Foundation.

Main causes and risk factors for hospitalisation in patients with primary Sjögren's syndrome. The major causes for hospitalisation were disease activity and infection and patients with hepatic involvement, vasculitis and more damage accrual had the highest risk for being hospitalised. PubMed, Clin Exp Rheumatol, 08/27/2015.

Cardiovascular

Is There an Increased Arterial Stiffness in Patients with primary Sjögren's syndrome (pSS)? Patients with pSS appear to have increased arterial stiffness, possibly caused by the use of steroids, hypertension and dyslipidemia. PubMed, Intern Med, 2016;55(5):455-9.

Central Nervous System

Clinical utility of circulating anti-N-methyl-d-aspartate receptor subunits NR2A/B antibody for the diagnosis of neuropsychiatric (NP) syndromes in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Circulating anti-NR2A/B antibody testing has a diagnostic value for NP syndromes in SLE and SS collectively. PubMed, Autoimmun Rev, 2017 Feb;16(2):114-122. (Also see SLE Symptoms)

Dry Eyes

Dry eyes are a symptom of Sjogren's syndrome.

Eye Problems Pain, redness and loss of vision are important problems that require medical attention. Eye problems can warn us of other health problems as well. familydoctor.org. (Also see Eye Involvement)

Dry mouth is a symptom of Sjogren's syndrome.

Red Lips Photography by Nolan LaTourelleScleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reabsorption, receding ligaments, and TMJ. ISN.

Androgens and Integrins in Salivary Glands in Sjögren's Syndrome (SS). In SS salivary glands androgen regulation was defective, which is likely to contribute to defective outside-in signaling, acinar atrophy, and ductal cell hyperplasia. P.Parola. Journal of Rheumatology.

Dry Vagina

Sjogren's Syndrome - 10 Things You Should Know. Some Sjogren's syndrome patients also experience dryness of the skin, vagina, nasal passages, and throat. VeryWell.

Quality of Sexual Life in Women with Primary Sjögren Syndrome (pSS). Both premenopausal and postmenopausal women with pSS have a worse sexual quality of life as they have a greater prevalence of dyspareunia. PubMed, J Rheumatol, 07/01/2015. (Also see Sexuality and Scleroderma)

Fatigue

Fatigue in primary Sjögren's (pSS) syndrome is associated with lower levels of proinflammatory cytokines. Cytokines, pain and depression appear to be the most powerful predictors of fatigue in pSS and our data challenges the notion that proinflammatory cytokines directly mediate fatigue in chronic immunological conditions. PubMed, RMD Open, 2016 Jul 19;2(2):e000282. (Also see Fatigue)

Fibromyalgia

Prevalence and clinical impact of fibromyalgia (FM) in patients with primary Sjögren's syndrome (pSS). The study showed that FM was prevalent in pSS and FM was associated with higher EULAR Sjögren's Syndrome Patient Reported Index and more severe depression. PubMed, Clin Exp Rheumatol, 08/27/2015. (Also see Fibromyalgia)

Gastrointestinal

Severe intestinal dysbiosis is prevalent in primary Sjögren's syndrome (pSS) and is associated with systemic disease activity. Severe intestinal dysbiosis is a prevalent finding in pSS and is associated both with clinical and laboratory markers of systemic disease activity as well as gastrointestinal inflammation. PubMed, Arthritis Res Ther, 2017 Oct 24;19(1):237.

Liver

Gastrointestinal and hepatic manifestations of Sjogren syndrome (SS). Several studies show that hepatitis C virus (HCV) is in saliva, although how this may impact sicca syndrome or SS in HCV is unclear. PubMed, J Clin Gastroenterol.

Pulmonary

Chronic Obstructive Pulmonary Disease Is Common in Never-smoking Patients with Primary Sjögren Syndrome (pSS). An obstructive pattern was the predominant pulmonary function test finding in patients with pSS, which suggest that superimposed restrictive lung disease per se is involved in the development of COPD. PubMed, J Rheumatol, 01/15/2015. (Also see Sjögren's Symptoms)

Renal

Renal involvement in primary Sjögren's syndrome (pSS): a prospective cohort study. Renal involvement in pSS is under–recognized with the most common manifestation being renal tubular acidosis presenting with hypokalemic paralysis. PubMed, Rheumatol Int, 2018 Dec;38(12):2251-2262.

Skin

Acquired neurocutaneous disorders. We discuss the pathophysiology and manifestation of various acquired neurocutaneous disorders. PubMed, Handb Clin Neurol, 2015;132:29-73.

Newborn Heart Problems

Women with Sjögren's have a higher risk of having lupus and other autoimmune diseases, and of their newborns having heart problems.

Pregnancy

Association between primary Sjögren's syndrome (pSS) and pregnancy complications: a systematic review and meta–analysis. There is an increased risk of fetal loss in pregnant patients with pSS and the presented evidence further supports multidisciplinary care for these patients to prevent complications during pregnancy. PubMed, Clin Rheumatol, 2016 Aug;35(8):1949-55.

Go to Sjogren's Syndrome: Diagnosis
 

Many thanks to our recent donors, Jack and Elizabeth Lewis, Network for Good, Shirley Miller, Reata Pharmaceuticals, and Chris Dokter! See ISN News for more donors. Click Here to Donate.

 

TOLL FREE HOTLINE, U.S. and Canada: 1-800-564-7099
Ask for our Free Info Packet by email or postal mail!

SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses.

We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected] to request our Welcome email, report bad links, or update page content. Disclaimer. Privacy Policy.
 

The most important thing in the world to know about scleroderma is sclero.org!

DONATE