Central Nervous System
Newborn Heart Problems
Sjogren's and Pregnancy
Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions.
Symptoms of Sjogren's Syndrome. Sjögren's is a systemic disease, and its symptoms are felt throughout the entire body. Sjogren's Syndrome Foundation.
Main causes and risk factors for hospitalisation in patients with primary Sjögren's syndrome. The major causes for hospitalisation were disease activity and infection and patients with hepatic involvement, vasculitis and more damage accrual had the highest risk for being hospitalised. PubMed, Clin Exp Rheumatol, 08/27/2015.
Prevalence of and factors associated with increased arterial stiffness in patients with primary Sjögren's syndrome (pSS). Women with pSS had higher pulse wave velocity (PWV) than controls. PubMed, Arthritis Care Res (Hoboken), 2014 Oct 9.
Hippocampal atrophy is associated with cerebrospinal fluid anti-NR2 antibodies in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Anti-NR2 antibodies cause neuronal death observed as reduced hippocampal grey matter in patients with SLE and pSS as previously demonstrated in mice with autoimmune disease. PubMed, Arthritis Rheumatol, 2014 Aug 22. (Also see SLE Symptoms)
Dry eyes are a symptom of Sjogren's syndrome.
Eye Problems Pain, redness and loss of vision are important problems that require medical attention. Eye problems can warn us of other health problems as well. familydoctor.org. (Also see Eye Involvement)
Dry Eye Disease Does Not Worsen With Time in Most Patients. Despite the general perception, dry eye disease does not necessarily worsen over time. Medscape, 12/30/2015.
Dry mouth is a symptom of Sjogren's syndrome.
Scleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reabsorption, receding ligaments, and TMJ. ISN.
Androgens and Integrins in Salivary Glands in Sjögren's Syndrome (SS). In SS salivary glands androgen regulation was defective, which is likely to contribute to defective outside-in signaling, acinar atrophy, and ductal cell hyperplasia. P.Parola. Journal of Rheumatology.
Sjogren's Syndrome - 10 Things You Should Know. Some Sjogren's syndrome patients also experience dryness of the skin, vagina, nasal passages, and throat. VeryWell.
Quality of Sexual Life in Women with Primary Sjögren Syndrome (pSS). Both premenopausal and postmenopausal women with pSS have a worse sexual quality of life as they have a greater prevalence of dyspareunia. PubMed, J Rheumatol, 07/01/2015. (Also see Sexuality and Scleroderma)
Fatigue in primary Sjögren's (pSS) syndrome is associated with lower levels of proinflammatory cytokines. Cytokines, pain and depression appear to be the most powerful predictors of fatigue in pSS and our data challenges the notion that proinflammatory cytokines directly mediate fatigue in chronic immunological conditions. PubMed, RMD Open, 2016 Jul 19;2(2):e000282. (Also see Fatigue)
Prevalence and clinical impact of fibromyalgia (FM) in patients with primary Sjögren's syndrome (pSS). The study showed that FM was prevalent in pSS and FM was associated with higher EULAR Sjögren's Syndrome Patient Reported Index and more severe depression. PubMed, Clin Exp Rheumatol, 08/27/2015. (Also see Fibromyalgia)
Severe intestinal dysbiosis is prevalent in primary Sjögren's syndrome (pSS) and is associated with systemic disease activity. Severe intestinal dysbiosis is a prevalent finding in pSS and is associated both with clinical and laboratory markers of systemic disease activity as well as gastrointestinal inflammation. PubMed, Arthritis Res Ther, 2017 Oct 24;19(1):237.
Gastrointestinal and hepatic manifestations of Sjogren syndrome (SS). Several studies show that hepatitis C virus (HCV) is in saliva, although how this may impact sicca syndrome or SS in HCV is unclear. PubMed, J Clin Gastroenterol.
Chronic Obstructive Pulmonary Disease Is Common in Never-smoking Patients with Primary Sjögren Syndrome (pSS). An obstructive pattern was the predominant pulmonary function test finding in patients with pSS, which suggest that superimposed restrictive lung disease per se is involved in the development of COPD. PubMed, J Rheumatol, 01/15/2015. (Also see Sjögren's Symptoms)
Renal involvement in primary Sjögren's syndrome (SS). The prevalence of renal SS, its presentation, likely pathogenesis and treatment is reviewed in this article. PubMed, Rheumatology (Oxford), 2015 Sep;54(9):1541-8. (Also see B Cells And T Cells)
Acquired neurocutaneous disorders. We discuss the pathophysiology and manifestation of various acquired neurocutaneous disorders. PubMed, Handb Clin Neurol, 2015;132:29-73.
Association between primary Sjögren's syndrome (pSS) and pregnancy complications: a systematic review and meta–analysis. There is an increased risk of fetal loss in pregnant patients with pSS and the presented evidence further supports multidisciplinary care for these patients to prevent complications during pregnancy. PubMed, Clin Rheumatol, 2016 Aug;35(8):1949-55.
United Way of Central New Mexico
United Way of Snohomish County
See ISN News for recent donors, including Juliet Youkhana; and donations in loving memory of Jim Miller and Arlene Marie Petulla.
Click Here to Donate or Shop
or click on the floating green DONATE sclero.org button.
SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to: