Treatments for Symptoms of Sjogren's Syndrome

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Treatments of Sjogren's: Overview
Treatments for Dry Eyes
Treatments for Dry Mouth
Treatment for Fatigue
Treatment for Renal Involvement

Overview of Treatments for Sjogren's

Treatments for Sjogren's may consist of therapies aimed at relieving specific symptoms, such as dry eyes or dry mouth, or targeted at trying to control the underlying disease process.

Clinical Trials: Sjögren's Syndrome. CenterWatch

Dry.Org - Internet Resources for Sjögren's Syndrome Dry.Org

Use of Biologics in Sjögren's Syndrome. In this review, we summarize the current evidence regarding B–cell targeted and anti–TNF therapies and provide an overview of promising drugs in the pipeline. Rheumatic Disease Clinics, 06/21/2016. (Also see Biologic Agents)

Optimizing conventional DMARD (cDMARD) therapy for Sjögren's syndrome (pSS). The unique and potent mechanisms of action to target immunopathology in pSS suggests that optimizing cDMARDs for treatment of pSS is worthwhile. ScienceDirect, Autoimmun Rev, 2018 May;17(5):480-492. (Also see DMARDs)

Safety of treatments for primary Sjögren’s syndrome. Synthetic DMARDs have not shown much efficacy in earlier studies, while biologic DMARDs show promising results regarding efficacy and cause mostly mild adverse events. PubMed, Expert Opin Drug Saf, 01/25/2016. (Also see DMARDs)

Efficacy and safety of belimumab given for 12 months in primary Sjögren's syndrome (SS): the BELISS open-label phase II study. Long–term treatment with belimumab may be beneficial in SS. PubMed, Rheumatology, 08/07/2015.

Treatment with belimumab restores B cell subsets and their expression of B cell activating factor (BAFF) receptor in patients with primary Sjogren's syndrome (pSS). Targeting BAFF with belimumab is successful in normalizing B cell frequency, phenotype and functions in pSS. PubMed, Rheumatology (Oxford), 03/03/2015. (Also see B Cells and T Cells)

Treatments for Dry Eyes

An innovative treatment for dry eyes. Could an exciting new procedure - involving the heating of the inside of the eyelids - cure dry eyes? The Telegraph, 02/09/2015.

Dry Eyes: Artificial Tears, Dry Eyes, Tears Naturale, Refresh, Refresh Plus, HypoTears, Lacrisert artificial tear inserts.

Gen-Teal Gel by CIBA Vision is an over-the-counter gel for dry eyes. It is best used at night, or along with liquid drops, as it can cause blurriness.

Treatments for Dry Mouth

Dry Mouth: Biotene products such as toothpaste, mouthwash, and gel; Salivert, Optimoist, Saliva Substitute, Moi-Stir, and Salix Lozenges.

Evoxac. This medication is used to treat symptoms of dry mouth due to Sjogren's Syndrome. MedicineNet.

Scleroderma Dental Involvement. Systemic scleroderma sometimes affects the mouth, teeth, jaw, and gums. It can cause the mouth to shrink, tooth loss, mouth sores, dry mouth, and jaw pain from TMJ. ISN.

Bone Resorption
Candida (Fungal)
Dental Amalgam
Dental Fears/Phobias
Dental Implants
General Dentistry
Microstomia (Small Mouth)
Microstomia Stories
Mouth Sores
Periodontal Disease
Photos of Dental Involvement
Scleroderma Dental
Sensitive Teeth
Stories of Scleroderma Dental
Sjogren's Syndrome
Taste and Smell
Tongue and Oral Cancers
Trigeminal Neuralgia
Xerostomia (Dry Mouth)

Treatments for Fatigue

Heat shock proteins (HSPs) and chronic fatigue in primary Sjögren's syndrome. Extracellular HSPs, particularly HSP90α, may signal fatigue in chronic inflammation. PubMed, Innate Immun, 2016 Apr;22(3):162-7.

Treatments for Renal Involvement

Kidney Failure. Lifelong efforts to control blood pressure and diabetes may be the best way to prevent chronic kidney disease and its progression to kidney failure. Usually, kidney function gradually decreases over time.

Go to Sjogren's Syndrome: Stories

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