|Treatments of Sjogren's: Overview
Treatments for Dry Eyes
Treatments for Dry Mouth
|Treatment for Fatigue
Treatment for Renal Involvement
Treatments for Sjogren's may consist of therapies aimed at relieving specific symptoms, such as dry eyes or dry mouth, or targeted at trying to control the underlying disease process.
Clinical Trials: Sjögren's Syndrome. CenterWatch
A Meta–Analysis of Treatment for Primary Sjögren's Syndrome. Reducing inflammation potentially improves salivary gland function. No individual immunomodulatory drug demonstrated consistent benefit in xerostomia and xerophthalmia. PubMed, Arthritis Care Res (Hoboken), 05/06/2019.
Use of Biologics in Sjögren's Syndrome. In this review, we summarize the current evidence regarding B–cell targeted and anti–TNF therapies and provide an overview of promising drugs in the pipeline. Rheumatic Disease Clinics, 06/21/2016. (Also see Biologic Agents)
Optimizing conventional DMARD (cDMARD) therapy for Sjögren's syndrome (pSS). The unique and potent mechanisms of action to target immunopathology in pSS suggests that optimizing cDMARDs for treatment of pSS is worthwhile. ScienceDirect, Autoimmun Rev, 2018 May;17(5):480-492. (Also see DMARDs)
Safety of treatments for primary Sjögren’s syndrome. Synthetic DMARDs have not shown much efficacy in earlier studies, while biologic DMARDs show promising results regarding efficacy and cause mostly mild adverse events. PubMed, Expert Opin Drug Saf, 01/25/2016. (Also see DMARDs)
Dry Eyes: Artificial Tears, Dry Eyes, Tears Naturale, Refresh, Refresh Plus, HypoTears, Lacrisert artificial tear inserts.
Gen-Teal Gel by CIBA Vision is an over-the-counter gel for dry eyes. It is best used at night, or along with liquid drops, as it can cause blurriness.
Dry Mouth: Biotene products such as toothpaste, mouthwash, and gel; Salivert, Optimoist, Saliva Substitute, Moi-Stir, and Salix Lozenges.
Evoxac. This medication is used to treat symptoms of dry mouth due to Sjogren's Syndrome. MedicineNet.
Scleroderma Dental Involvement. Systemic scleroderma sometimes affects the mouth, teeth, jaw, and gums. It can cause the mouth to shrink, tooth loss, mouth sores, dry mouth, and jaw pain from TMJ. ISN.
Microstomia (Small Mouth)
Photos of Dental Involvement
Stories of Scleroderma Dental
Taste and Smell
Tongue and Oral Cancers
Xerostomia (Dry Mouth)
Heat shock proteins (HSPs) and chronic fatigue in primary Sjögren's syndrome. Extracellular HSPs, particularly HSP90α, may signal fatigue in chronic inflammation. PubMed, Innate Immun, 2016 Apr;22(3):162-7.
Kidney Failure. Lifelong efforts to control blood pressure and diabetes may be the best way to prevent chronic kidney disease and its progression to kidney failure. Usually, kidney function gradually decreases over time. MedicineNet.com.
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