Osteoporosis in Scleroderma

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Bone Density
Osteoporosis and Scleroderma
Media Stories
Patient Stories


Osteoporosis is when the bone density is low causing the bones to become porous and prone to fractures. In scleroderma, bone density can decrease due to certain medications, a decrease in exercise, change in diet and factors of the disease itself. It is important to discuss this with your doctor, especially if you have a history of osteoporosis in your family. ISN.

Osteoporosis occurs when the rate of bone resorption exceeds the rate of bone formation creating "porous bones." Most cases of osteoporosis occur as an acceleration of this normal aging process. The condition can also be caused by other disease processes or prolonged use of certain medications that result in bone loss. (Also see Bone Resorption)

Current status of the influence of osteoporosis on periodontology and implant dentistry. The impact of osteoporosis on the periodontal and peri–implant tissues was reviewed to emphasize the importance of oral hygiene measures, and the combined medical/dental assessment when osteoporotic patients are in need of dentoalveolar surgical procedures. PubMed, Curr Opin Endocrinol Diabetes Obes, 2016 Dec;23(6):435-439. (Also see Dental Implants)

The incidence and risk of osteoporosis in patients with anxiety disorder (AD): A Population–based retrospective cohort study. The risk ratios are the highest for osteoporosis within 1 year of AD diagnosis, but the risk remains statistically significant for »1 year and clinicians should pay particular attention to osteoporotic comorbidities in AD patients. PubMed, Medicine (Baltimore), 2016 Sep;95(38):e4912. (Also see Anxiety and Attitude)

Significant bone microarchitecture impairment in premenopausal women with active celiac disease (CD). Patients with symptomatic CD had a greater bone microarchitectural deficit than those with subclinical CD. Bone, 03/14/2015. (Also see Celiac Disease)

Bone Density

Bone Density or Bone Mineral Density (BMD) is a measurement of the compactness of the bone or the amount of bone mass per square centimeter. Bone density measurements are used to diagnosis osteopenia, osteoporosis and fracture risk. ISN.

Incidence and predictors of osteoporotic fractures in patients with Barrett's oesophagus (BO): a population–based nested case–control study. The incidence of osteoporotic fractures was not increased in BO patients compared to the general population and proton pump inhibitors use was not associated with increased fracture risk. PubMed, Aliment Pharmacol Ther, 10/05/2017. (Also see Esophageal (Throat) Involvement)

Bone mineral density (BMD) is decreased in fibromyalgia syndrome (FMS): a systematic review and meta–analysis. In this meta–analysis, we observe that BMD at lumbar spine is decreased in FMS compared with normal individuals. PubMed, Rheumatol Int, 12/05/2016. (Also see Fibromyalgia)

Proton pump inhibitors use and change in bone mineral density. The results of this study showed that PPI use in subjects without risk factors of osteoporosis determined by the femoral T–score compared with the control group was associated with increased risk of developing osteoporosis and osteopenia in the femur bones. Wiley Online Library, 05/31/2016.

Impact of treatment with inhaled corticosteroids (ICS) on bone mineral density (BMD) of patients with asthma: related with age. This study indicates that BMD reduction in ICS users with asthma is dependent on age and appears that younger patients are at greater risk of BMD loss. PubMed, Osteoporos Int, 04/10/2015. (Also see Asthma Treatments)

Osteoporosis and Scleroderma

Trabecular Bone Score (TBS) in Female Patients with Systemic Sclerosis (SSc): Comparison with Rheumatoid Arthritis and Influence of Glucocorticoid (GC) Exposure. SSc-related bone involvement is characterized by an impairment in bone quality in addition to reduced bone quantity, and TBS can identify the negative effect of GC on bone microarchitecture. PubMed, J Rheumatol, 12/01/2014. (Also see Osteoporosis and Glucocorticoids, Steroids (Prednisone)

Increased risk of osteoporotic fractures in patients with systemic sclerosis (SSc): a nationwide population-based study. SSc patients had a high increased risk of vertebral and hip fractures, especially those who were female, older, or used a high dose of corticosteroid (> 7.5 mg) or experienced bowel dysmotility. PubMed, Ann Rheum Dis, 2014 Feb 14. (Also see Steroid Warnings for Scleroderma)

Treatments for Osteoporosis

Osteoporosis Treatments and Care. Osteoporosis treatments come in several forms. Many should be started during childhood; others include prescription drugs to treat osteoporosis. Get an overview. WebMD.

Eighteen Months of Treatment With Subcutaneous Abaloparatide (ABL-SC) Followed by 6 Months of Treatment With Alendronate in Postmenopausal Women With Osteoporosis. Use of ABL-SC for 18 months followed by ALN for 6 months improved bone mineral density and reduced fracture risk throughout the skeleton and may be an effective treatment option for postmenopausal women with osteoporosis. PubMed, Mayo Clin Proc, 2017 Feb;92(2):200-210.

Treatment needs and current options for postmenopausal osteoporosis. The more recent advances in bone biology identified new targets for the development of drugs with a more potent and selective activity on either osteoclasts or osteoblasts. PubMed, Expert Opin Pharmacother, 04/07/2016.

Current approaches to osteoporosis treatment. Substantial progress has been made in the past several years in the understanding and modification of osteoporosis management. PubMed, Curr Opin Rheumatol. 2015 May;27(3):216-24.

Media Stories

Men's Bone Health Is Largely Ignored. A third of all hip fractures happen in men, and in the year after a fracture, men are twice as likely to die as women. Time Healthland, 10/10/2014.

Patient Stories

Edith: MCTD with En Coup de Sabre/Parry Romberg's, Lichen Sclerosus, Rheumatoid Arthritis, Sjogren's My GP is fabulous, but at the end of the day it is not enough. I would be lost without people like you…

Susie: CREST Syndrome I have had CREST syndrome for the past eight years. My specialist is Dr. Frederick Wigley, from Johns Hopkins…

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