Nailfold videocapillaroscopy can be used to assess the digital ulcer risk in people who have systemic sclerosis (SSc, scleroderma). Nailfold studies are also useful for diagnosis of systemic scleroderma. (Also see Fingernails, Fingerprints, Nailfolds, and Cuticles)
Capillaroscopy changes are associated with disease progression in patients with early systemic sclerosis (SSc): A prospective study. An active or a late pattern on capillaroscopy was an independent predictive risk factor for the development of SSc. PubMed, Int J Rheum Dis, 05/02/2019.
Predicting cardiopulmonary involvement in patients with systemic sclerosis: complementary value of nailfold videocapillaroscopy (NVC) patterns and disease–specific autoantibodies. All SSc–specific auto–antibodies were found, with ACA and anti-Scl-70 being the most prevalent and the association between NVC–pattern and heart/lung involvement was independent of specific anti-ENA antibodies, which might indicate microangiopathy is an important cause of organ involvement. PubMed, Rheumatology (Oxford), 12/10/2016. (Also see Antibodies and Scleroderma Cardiac (Heart) Involvement)
At–risk systemic sclerosis (SSc) patients can be identified using nailfold videocapillaroscopy ( NVC) a non–invasive imaging technique. The results supported the use of NVC as a routine strategy to evaluate patients with systemic sclerosis and to identify those at higher risks of disease progression and severity. Scleroderma News, 03/08/2016.
Late nailfold videocapillaroscopy (NVC) patterns associated with hand calcinosis and acro-osteolysis in systemic sclerosis (SSc). Acro–osteolysis and calcinosis are independently associated with the late NVC pattern, and particularly with severe capillary loss. PubMed, Arthritis Care Res (Hoboken), 2016 Mar;68(3):366-73. (Also see Bone Resorption in SSc and Calcinosis)
Nailfold capillaroscopic (NVC) parameters and skin telangiectasia patterns in patients with systemic sclerosis. The severity of nailfold microangiopathy seems to correlate in SSc patients with both progressive cutaneous microvascular abnormalities and Medsger's severity score, as evaluated by NVC analysis and dermoscopy. PubMed, Microvasc Res, 2017 May;111:20-24. (Also see Vascular Involvement and Telangiectasia)
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