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Nailfold Videocapillaroscopy for Digital Ulcer Risk in Systemic Sclerosis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Nailfold videocapillaroscopy can be used to assess the digital ulcer risk in people who have systemic sclerosis (SSc, scleroderma). Nailfold studies are also useful for diagnosis of systemic scleroderma. (Also see Fingernails, Fingerprints, Nailfolds, and Cuticles)

Nailfold Videocapillaroscopy (NVC) is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis (SSc) and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients (ILD). NVC should be considered in the diagnostic assessment of ILD patients regardless of the presence of Raynaud’s Phenomenon. PubMed, Diagnostics (Basel), 2020 Apr 25;10(5). (Also see Pulmonary Fibrosis Diagnosis)

Capillaroscopy changes are associated with disease progression in patients with early systemic sclerosis (SSc): A prospective study. An active or a late pattern on capillaroscopy was an independent predictive risk factor for the development of SSc. PubMed, Int J Rheum Dis, 05/02/2019.

Predicting cardiopulmonary involvement in patients with systemic sclerosis: complementary value of nailfold videocapillaroscopy (NVC) patterns and disease–specific autoantibodies. All SSc–specific auto–antibodies were found, with ACA and anti-Scl-70 being the most prevalent and the association between NVC–pattern and heart/lung involvement was independent of specific anti-ENA antibodies, which might indicate microangiopathy is an important cause of organ involvement. PubMed, Rheumatology (Oxford), 2017 Jul 1;56(7):1081-1088. (Also see Antibodies and Scleroderma Cardiac (Heart) Involvement)

Late nailfold videocapillaroscopy (NVC) patterns associated with hand calcinosis and acro-osteolysis in systemic sclerosis (SSc). Acro–osteolysis and calcinosis are independently associated with the late NVC pattern, and particularly with severe capillary loss. PubMed, Arthritis Care Res (Hoboken). (Also see Bone Resorption in SSc and Calcinosis)

Nailfold capillaroscopic (NVC) parameters and skin telangiectasia patterns in patients with systemic sclerosis. The severity of nailfold microangiopathy seems to correlate in SSc patients with both progressive cutaneous microvascular abnormalities and Medsger's severity score, as evaluated by NVC analysis and dermoscopy. PubMed, Microvasc Res, 2017 May;111:20-24. (Also see Vascular Involvement and Telangiectasia)

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