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Wound Healing in Systemic Scleroderma

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Overview

Wounds are supposed to heal — not stay the same or get worse.
So the choice is very simple — hire a doctor, or a hearse!

Wound healing can be a real challenge for many systemic scleroderma patients. Wounds include accidental cuts and abrasions, puncture wounds, and microvascular damage such as digital ulcers. Any wound that does not show improvement after a usual period of time should be brought to your doctor's attention.

They used to advise all scleroderma patients to avoid surgery whenever possible, due to concerns about wound healing. Now that is not a blanket recommendation, but rather is an issue to be considered on an individual basis. (Also see What is Scleroderma?, Digital Ulcer Treatments and Gangrene)

Fibroblasts in fibrosis: novel roles and mediators. In addition to the extensive extracellular matrix fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. Pub Med Front Pharmacol, 2014 May 27;5:123. (Also see Causes of Scleroderma: Fibroblasts)

Sticking it to Scleroderma: Potential Therapies Blocking Elevated Adhesive and Contractile Signaling. During repair of connective tissue, resting fibroblasts become `activated'; that is, they migrate into the wound where they synthesize and remodel new extracellular matrix. Leask, Andrew. (IngentaConnect) Current Enzyme Inhibition, Vol. 6, No. 2, July 2010, 97-104(8). (Also see Fibroblasts)

Medical Maggots™ (maggot therapy, maggot debridement therapy, MDT, biotherapy, biosurgery, biodebridement, larval therapy). Maggot therapy is the controlled, therapeutic use of live blow fly larvae ("maggots") to treat skin and soft tissue wounds. Monarch Labs.

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