Vaccinations and Scleroderma

Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases

Author: Janey Willis. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview of Vaccinations and Autoimmunity
Covid-19 Vaccination
Seasonal Flu Vaccination
H1N1 Vaccination
Pneumonia Vaccination


Scleroderma patients should always consult their physician before receiving a vaccination of any kind.

Vaccinations such as flu shots and pneumonia shots are recommended for patients with scleroderma and other autoimmune diseases. However, scleroderma patients should always consult their physician before being vaccinated. (Also see What is Scleroderma?, Medical Overview, and Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases)

Systemic Sclerosis and Vaccinations. Age over 65 years old, interstitial lung disease, and ongoing immunosuppressive therapy were significantly related with acceptance to both vaccinations using univariate analyses. PubMed, Vaccines (Basel), 2020 Apr 28;8(2).

Most People Worldwide Trust That Vaccines Are Safe – But the Number Who Don't Is Concerning. The majority of people worldwide think vaccines are safe, according to a new global survey – but the share of doubters is still high enough to threaten immunity. Time Healthland, 06/19/2019.

Human papillomavirus vaccination and the risk of autoimmune disorders: A systematic review and meta –analysis. No evidence of an association between HPV vaccination and ADs was found. PubMed, Vaccine, 04/26/2019. (Also see Causes of Scleroderma: Vaccinations)

Vaccine–induced autoimmunity: the role of molecular mimicry and immune crossreaction. In this review, we address the concept of molecular mimicry and its application in explaining post vaccination autoimmune phenomena. PubMed, Cell Mol Immunol, 2018 Jun;15(6):586-594. (Also see Causes of Scleroderma: Vaccinations)

Covid-19 Vaccination

5 Things to Know About a COVID Vaccine: It Won’t Be a ‘Magic Wand ’. Even after a vaccine wins Food and Drug Administration approval, there would be a long wait before it’s time to declare victory over the virus. Kaiser Health News, 10/05/2020.

NIH ‘Very Concerned’ About Serious Side Effect in Coronavirus Vaccine Trial. The Food and Drug Administration is weighing whether to follow British regulators in resuming a coronavirus vaccine trial that was halted when a participant suffered spinal cord damage. Kaiser Health News, 09/14/2020.

Johnson & Johnson to test coronavirus vaccine in 60,000 volunteers. Johnson & Johnson aims to test its experimental coronavirus vaccine in up to 60,000 volunteers in a late-stage trial scheduled to start in September, according to a U.S. government database of clinical trials. Reuters Health, 08/20/2020.

Wave of promising study results raises hopes for coronavirus vaccines. Early data from trials of three potential COVID-19 vaccines increased confidence that a vaccine can train the immune system to recognize and fight the novel coronavirus without serious side effects. Reuters Health, 07/20/2020.

Multiple vaccine candidates show early promise; inhaled interferon helps severe COVID-19 patients. Here is a brief roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19. Reuters Health, 07/20/2020.

A New Entry in the Race for a Coronavirus Vaccine: Hope. Scientists are increasingly optimistic that a vaccine can be produced in record time, but getting it manufactured and distributed will pose huge challenges. New York Times, 05/20/2020.

Seasonal Flu Vaccination

Key Facts About Seasonal Flu Vaccine. Vaccination has been shown to have many benefits including reducing the risk of flu illnesses, hospitalizations and even the risk of flu-related death in children. Centers for Disease Control and Prevention, 09/11/2020.

H1N1/Flu Vaccination

Experts suggest vaccines for those with chronic illness like heart diseases.

Pandemic non–adjuvanted influenza A H1N1 vaccine in a cohort of patients with systemic sclerosis (SSc). The non–adjuvanted influenza H1N1 virus vaccine proved to be safe and effective, independent of SSc clinical subtype, disease severity or therapy. PubMed, Rheumatology (Oxford), 09/08/2017.

Pneumonia Vaccination

The pneumonia vaccine (pneumococcal vaccine or PPV23 or PPSV) is recommended for adults over 65 and younger persons with chronic illnesses or weakened immune systems. According to UpToDate® a 2009 meta-analysis on the efficacy of PPV23 suggests that the pneumococcal vaccination appears to be more beneficial in the prevention of invasive pneumococcal disease, rather than in the prevention of pneumonia. Scleroderma patients should discuss the pros and cons of this vaccine with their physicians. ISN.

Pneumococcal Vaccination (Pneumonia Vaccination). Pneumococcal vaccination is a method of preventing a specific type of lung infection (pneumonia) that is caused by Pneumococcus bacterium. There are more than 80 different types of pneumococcus bacteria-23 of these are covered in the current vaccination.

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