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Systemic Sclerosis (Scleroderma) in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview of Polyautoimmunity
Scleroderma in Overlap
Connective Tissue Disease (CTD)
Mixed Connective Tissue Disease (MCTD)
Multiple Autoimmune Syndrome
Shared Autoimmunity
Undifferentiated Connective Tissue Disease (UCTD)
Overlap Patient and Caregiver Stories

Overview of Polyautoimmunity

Scleroderma, or scleroderma symptoms, can occur in overlap with other illnesses. (Also see What is Scleroderma?, Types of Scleroderma and Systemic Symptoms)

Overlap connective tissue disease syndromes. Overlap Syndromes (OSs) have been defined as entities satisfying classification criteria of at least two connective tissue diseases (CTDs) occurring at the same or at different times in the same patient. Autoimmun Rev.

Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome. Data suggest that polyautoimmunity and MAS are not independent traits and that gender, age, and age of onset are interrelated factors influencing autoimmunity. PubMed, J Immunol Res, 2015;2015:572353. (Also see Multiple Autoimmune Syndrome)

Scleroderma in Overlap

Scleroderma in Overlap. When Systemic Sclerosis (in either the Limited or the Diffuse form) appears in conjunction with features of one or more other connective tissue diseases (such as Systemic Lupus Erythematosus, Polymyositis, Dermatomyositis) it is called "overlap." ISN.

Overview
Overlap with Lupus
Overlap with Myopathies
Case Reports of Overlaps

Connective Tissue Disease (CTD)

Connective Tissue Disease (CTD). Connective tissue diseases include systemic lupus erythematosus, rheumatoid arthritis, scleroderma, polymyositis, and dermatomyositis. ISN.

Mixed Connective Tissue Disease (MCTD)

Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. ISN.

Overview
Symptoms
MCTD and Scleroderma

Multiple Autoimmune Syndrome (MAS)

Multiple Autoimmune Syndrome (MAS) is the coexistence of three or more autoimmune diseases. At least one of them is usually a skin disease, such as psoriasis or scleroderma. ISN.

Undifferentiated Connective Tissue Disease (UCTD)

Undifferentiated Connective Tissue Disease (UCTD). When a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called Undifferentiated Connective Tissue Disease. ISN.

Shared Autoimmunity

Shared Autoimmunity is a rather loose term. It variously refers to autoantibodies, symptoms, or presence of autoimmune diseases within the same patient or within several or more members of the same family. ISN.

Overlap Patient & Caregiver Stories

Andi P: UCTD and Possible Scleroderma It is believed that I do have an autoimmune disease they are not sure if it is systemic or not, but I know what I live through on a daily basis…

Angela S: Overlap Syndrome I am twenty-five years old and I was diagnosed with polymyositis and scleroderma, rheumatoid arthritis, mitral valve prolapse, a heart murmur, and pericarditis…

Annette G: MCTD, Systemic Scleroderma, Chronic Kidney Disease, CFS, Fibromyalgia, Trigeminal Neuralgia, TMJ People think that because I am a nurse I have all the answers. Well guess what? I don't…

More Overlap Patient and Caregiver Story Listings…

Go to Connective Tissue Disease
 
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