SCLERO.ORG
Search

Mixed Connective Tissue Disease (MCTD)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Symptoms
MCTD and Scleroderma

Overview

Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. (Also see Lupus, Systemic Sclerosis, Polymyositis, and Antibodies)

Mixed Connective Tissue Disease consists of the following core clinical and laboratory features: Raynaud phenomenon, swollen hands, arthritis/arthralgia, acrosclerosis, esophageal dysmotility, myositis, pulmonary hypertension, high level of anti-U1-RNP antibodies, and antibodies against U1-70 kd small nuclear ribonucleoprotein (snRNP). Medscape.

(Case Report): Posterior reversible encephalopathy syndrome in a patient with mixed connective tissue disease. It is hard to accurately determine whether posterior reversible encephalopathy syndrome in this case is a complication of cyclophosphamide or a condition that resulted from the mixed connective tissue disease flare-up. BioMed Central, Journal of Medical Case Reports 2016.

Symptoms

Case Report: Following leads: connecting dysphagia to mixed connective tissue disease. High–dose corticosteroids and methotrexate were given with little improvement, followed by intravenous immunoglobulin with progressive remission of symptoms. PubMed, BMJ Case Rep, 2018 Mar 5;2018.

Sensorineural hearing loss as a common manifestation in patients with mixed connective tissue disease. Raynaud's phenomenon, antiphospholipid and antiendothelial cell antibodies, increased serum levels of proinflammatory cytokines and a reduced number of regulatory T cells were found to be associated with sensorineural hearing loss in mixed connective tissue disease patients. International Journal of Clinical Rheumatology. (Also see Autoimmune Ear Disease)

(Case Report) Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration. Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. Springerlink, Neurological Sciences. (Also see Myopathy)

Digital (Finger) Ulcer from Mixed Connective Tissue Disease (MCTD). This digital ulcer is 14 weeks old. It was caused by secondary Raynaud's phenomenon, in a patient with Mixed Connective Tissue Disease (MCTD). The MCTD was diagnosed 5 years ago, after thyroid gland removal. ISN Photo Repository, contributed by Jeanne N.

MCTD and Systemic Sclerosis (Scleroderma)

Disease evolution in mixed connective tissue disease (MCTD): results from a long–term nationwide prospective cohort study. Long-term remission in MCTD is not frequent; however, the low systemic lupus erythematosus disease activity index 2000 and EUSTAR scores during the observation period suggests that the disease runs a milder course than systemic lupus erythematosus and systemic sclerosis. PubMed, Arthritis Res Ther, 2017 Dec 21;19(1):284.

Connective tissue diseases: systemic sclerosis: beyond limited and diffuse subsets? A new study now proposes that patients with systemic sclerosis and overlapping features of another connective tissue disease might form a distinct disease subset. PubMed, Nat Rev Rheumatol.

(Case Report) Scleroderma renal crisis in a newly diagnosed mixed connective tissue disease (MCTD) resulting in dialysis-dependent chronic kidney disease despite angiotensin-converting enzyme inhibition. A case of MCTD consisting of scleroderma, Sjögren's syndrome and polymyositis complicated by scleroderma renal crisis (SRC) but with negative anti-nuclear antibody (ANA), anti-Scl 70 and anti-centromere antibodies. Springerlink. (Also see Scleroderma Renal Crisis)

Go to Multiple Autoimmune Syndrome
 

See ISN News for recent donors. Click Here to Donate.

 

TOLL FREE HOTLINE, U.S. and Canada: 1-800-564-7099
Ask for our Free Info Packet by email or postal mail!

SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses.

We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected] to request our Welcome email, report bad links, or update page content. Disclaimer. Privacy Policy.
 

The most important thing in the world to know about scleroderma is sclero.org!