Scleroderma in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overlap with Lupus
Overlap with Myopathies
Case Reports of Overlaps


When Systemic Sclerosis (in either the Limited or the Diffuse form) appears in conjunction with features of one or more other connective tissue diseases it is called "overlap." (Also see What is Scleroderma?)

Immunogenetics of systemic sclerosis (SSc): Defining heritability, functional variants and shared-autoimmunity pathways. The genetic overlap between SSc and other autoimmune diseases is explored. PubMed, October 2015.

Overlap Syndrome Distinct in Scleroderma (SSc). This study demonstrates that patients with SSc overlap, on average, carry a higher disease burden than patients with the Limited form. Medpage Today, 03/10/2015.

Scleroderma in Overlap with Lupus

Assessing Systemic Lupus Erythematous (SLE)-Scleroderma (SSc) Combo — What are outcomes for patients with both conditions? Patients with SSc–SLE were equally likely to experience renal crisis, interstitial lung disease, or digital ulcers. Medpage Today, 10/20/2018. (Also see Lupus Media Stories)

Anti-neutrophil cytoplasmic antibody negative crescentic paucimmune glomerulonephritis in a case of scleroderma with systemic lupus erythematosus (SLE) overlap. In scleroderma and SLE overlap syndrome, the renal findings may vary being a combination of features of immune complex mediated glomerulonephritis as well as thrombotic microangiopathy. PubMed, Saudi J Kidney Dis Transpl, 2016 May;27(3):602-5.

Disease progression in systemic sclerosis (SSc)-overlap syndrome is significantly different from limited (IcSSc) and diffuse cutaneous systemic sclerosis (dcSSc). SSc-overlap syndromes should be regarded as a separate SSc subset, distinct from lcSSc and dcSSc, due to a different progression of the disease, different proportional distribution of specific autoantibodies, and of different organ involvement. PubMed, Ann Rheum Dis, 2015 Apr;74(4):730-7.

Scleroderma in Overlap with Myopathies

Clinical characteristics of scleroderma overlap syndromes (SOV): comparisons with pure scleroderma. SOV rather than pure scleroderma presented in younger Thai scleroderma patients and scleroderma–polymyositis overlap was the most common subtype and its clinical features were similar to those of pure scleroderma. PubMed, Int J Rheum Dis, 04/29/2016.

Clinical and laboratory features of overlap syndromes (OS) of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. This is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. PubMed, Clin Rheumatol. (Also see Myopathy and Myositis, Lupus in Overlap and Rheumatoid Arthritis in Overlap)

Case Reports of Scleroderma in Overlap

(Case Report) Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases? The coexistence of features of chronic cutaneous lupus erythematosus and scleroderma in the same skin lesions is very infrequent and has only been reported in 3 patients. Journal of the American Academy of Dermatology. (Also see Lupus)

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