Undifferentiated Connective Tissue Disease (UCTD)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

When a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called Undifferentiated Connective Tissue Disease (UCTD). (Also see Difficult Diagnosis)

Cardiac involvement in undifferentiated connective tissue disease (UCTD) at risk for systemic sclerosis (SSc) (otherwise referred to as very early–early systemic sclerosis): a TDI study. Our study shows that UCTD–risk–SSc patients show a previously unrecognized, mild biventricular systolic and diastolic dysfunction as compared to controls. PubMed, Clin Exp Med, 2018 May;18(2):237-243.

Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases (UCTD) subjects: what's on the horizon? The high prevalence of anti-DFS70 antibodies in the UCTD patients suggested the potential role of these autoantibodies as a marker in the evolution of UCTD to CTD. PubMed, Rheumatology (Oxford), 04/03/2018. (Also see Antibodies)

Undifferentiated connective tissue disease (UCTD): predictors of evolution into definite disease. High ANA titres or the presence of cytopenias at baseline, as well as progression of nailfold–capillaroscopy pattern during follow–up, are the leading factors associated with evolution to definite CTD. PubMed, Clin Exp Rheumatol, 2017 Sep-Oct;35(5):739-745.

Interstitial pneumonia (ILD) with autoimmune features and undifferentiated connective tissue disease (UCTD): Our interdisciplinary rheumatology–pneumology experience, and review of the literature. The cooperation between multidisciplinary groups with different experiences may be advisable for a validation study of the proposed nomenclature and classification criteria of these indefinable ILD/CTD variants. PubMed, Autoimmun Rev, 2016 Jan;15(1):61-70.

An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. This task force proposes the term "interstitial pneumonia with autoimmune features" (IPAF) and offers classification criteria. European Respiratory Journal, 07/09/2015.

Undifferentiated Connective Tissue Disease at risk for Systemic Sclerosis (SSc) (so far referred to as very early/early SSc or pre-SSc). This nosographic approach is instrumental to plan future studies devoted to investigate validated biomarkers heralding the development of major vascular disease manifestations as well as skin and/or organ fibrosis in patients at risk. PubMed, Autoimmun Rev, 2015 Mar;14(3):210-3.

Case Report: Primary anetoderma with undifferentiated connective tissue disease. The diagnosticuncertainty of this case led to added difficulty in management of a disease that is already notoriously difficult to treat and may significantly impact patient's quality of life. PubMed, Dermatol Online J.

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